Weight loss cuts A-fib events in obese patients
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“Atrial fibrillation has been described as the epidemic of the new millennium, with a projection that by 2050 there will be 12 million to 15 million affected individuals in the United States. In the United States, the direct economic cost of atrial fibrillation is estimated at $6 billion annually. Although population aging is regarded as an important contributor, obesity may account for a substantial proportion of the increasing prevalence,” according to background information in the article. Whether weight reduction and cardiometabolic risk factor management can reduce the burden of atrial fibrillation has not been known. The study was conducted between June 2010 and December 2011 among overweight and obese patients with symptomatic atrial fibrillation.
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Weight reduction decreases atrial fibrillation and symptom severity
The weight-loss intervention included a very low calorie diet, meal replacements, a written exercise plan, behavioral modification and in-person clinic visits every three months. Routine care consisted of written and verbal advice on nutrition and exercise. Controls were prescribed fish oil (3 g/day), unless they were taking dual antiplatelet agents or oral anticoagulants. In addition to more weight loss, the intervention group also experienced significantly greater reductions in atrial fibrillation symptom burden scores, symptom severity scores, number of episodes, and cumulative duration, compared with the control group, as follows: Symptom severity scores in the intervention group declined 8.4 points compared with 1.7 points among controls (P<0.001) The average number of atrial fibrillation episodes declined an average of 2.5 events in the intervention group compared with no change in controls (P=0.01) Cumulative atrial fibrillation duration decreased 692 minutes in the intervention group compared with 419 minutes among controls (P=0.002). In both the intervention and control groups, there was a reduction in interventricular septal thickness (1.1 mm vs. 0.6 mm, P=0.02, respectively) and left atrial area (3.5 cm2 vs.
For the original version including any supplementary images or video, visit http://www.clinicaladvisor.com/weight-loss-cuts-a-fib-events-in-obese-patients/article/321473/